Magnetic Seizure Therapy for the Treatment of Depression


Book Section

© 2015 by Wiley-Blackwell. All rights reserved. The magnetic approach to seizure therapy is based on the hypothesis that the electrical currents induced in deep brain structures by electroconvulsive therapy (ECT) may contribute to the adverse cognitive side effects. This chapter reviews the rationale for magnetic seizure therapy (MST), technical aspects of its delivery, and the body of evidence spanning computational modeling, preclinical animal studies, and human trials. The aim of MST is to retain the unparalleled efficacy of ECT with fewer cognitive side effects via reduced impact on deep brain structures thought to be involved in the cognitive side effects of ECT, such as the hippocampus. The development of MST was an interdisciplinary and translational effort involving device development, nonhuman primate (NHP) studies, and clinical trials. Individualized low amplitude seizure therapy (iLAST) captures both features (low and individualized currents), and generalizes the concept across electrical and magnetic modes of seizure induction.

Full Text

Duke Authors

Cited Authors

  • Lisanby, SH; Deng, ZD

Published Date

  • June 5, 2015

Book Title

  • Brain Stimulation: Methodologies and Interventions

Start / End Page

  • 123 - 148

International Standard Book Number 13 (ISBN-13)

  • 9781118568293

Digital Object Identifier (DOI)

  • 10.1002/9781118568323.ch8

Citation Source

  • Scopus