Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology.

Journal Article (Journal Article)

This portion of the NCCN Guidelines for Colon Cancer focuses on the use of systemic therapy in metastatic disease. Considerations for treatment selection among 32 different monotherapies and combination regimens in up to 7 lines of therapy have included treatment history, extent of disease, goals of treatment, the efficacy and toxicity profiles of the regimens, KRAS/NRAS mutational status, and patient comorbidities and preferences. Location of the primary tumor, the BRAF mutation status, and tumor microsatellite stability should also be considered in treatment decisions.

Full Text

Duke Authors

Cited Authors

  • Benson, AB; Venook, AP; Cederquist, L; Chan, E; Chen, Y-J; Cooper, HS; Deming, D; Engstrom, PF; Enzinger, PC; Fichera, A; Grem, JL; Grothey, A; Hochster, HS; Hoffe, S; Hunt, S; Kamel, A; Kirilcuk, N; Krishnamurthi, S; Messersmith, WA; Mulcahy, MF; Murphy, JD; Nurkin, S; Saltz, L; Sharma, S; Shibata, D; Skibber, JM; Sofocleous, CT; Stoffel, EM; Stotsky-Himelfarb, E; Willett, CG; Wu, CS; Gregory, KM; Freedman-Cass, D

Published Date

  • March 2017

Published In

Volume / Issue

  • 15 / 3

Start / End Page

  • 370 - 398

PubMed ID

  • 28275037

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2017.0036


  • eng

Conference Location

  • United States