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Niclosamide: Beyond an antihelminthic drug.

Publication ,  Journal Article
Chen, W; Mook, RA; Premont, RT; Wang, J
Published in: Cell Signal
January 2018

Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those caused by parasites. These diseases and symptoms may include cancer, bacterial and viral infection, metabolic diseases such as Type II diabetes, NASH and NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis. Among the underlying mechanisms associated with the drug actions of niclosamide are uncoupling of oxidative phosphorylation, and modulation of Wnt/β-catenin, mTORC1, STAT3, NF-κB and Notch signaling pathways. Here we provide a brief overview of the biological activities of niclosamide, its potential clinical applications, and its challenges for use as a new therapy for systemic diseases.

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Published In

Cell Signal

DOI

EISSN

1873-3913

Publication Date

January 2018

Volume

41

Start / End Page

89 / 96

Location

England

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Scleroderma, Systemic
  • Rats
  • Niclosamide
  • Neoplasms
  • Mice
  • Infections
  • Humans
  • Female
  • Endometriosis
 

Citation

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Chen, W., Mook, R. A., Premont, R. T., & Wang, J. (2018). Niclosamide: Beyond an antihelminthic drug. Cell Signal, 41, 89–96. https://doi.org/10.1016/j.cellsig.2017.04.001
Chen, Wei, Robert A. Mook, Richard T. Premont, and Jiangbo Wang. “Niclosamide: Beyond an antihelminthic drug.Cell Signal 41 (January 2018): 89–96. https://doi.org/10.1016/j.cellsig.2017.04.001.
Chen W, Mook RA, Premont RT, Wang J. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89–96.
Chen, Wei, et al. “Niclosamide: Beyond an antihelminthic drug.Cell Signal, vol. 41, Jan. 2018, pp. 89–96. Pubmed, doi:10.1016/j.cellsig.2017.04.001.
Chen W, Mook RA, Premont RT, Wang J. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89–96.
Journal cover image

Published In

Cell Signal

DOI

EISSN

1873-3913

Publication Date

January 2018

Volume

41

Start / End Page

89 / 96

Location

England

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Scleroderma, Systemic
  • Rats
  • Niclosamide
  • Neoplasms
  • Mice
  • Infections
  • Humans
  • Female
  • Endometriosis