Niclosamide: Beyond an antihelminthic drug.

Published

Journal Article (Review)

Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those caused by parasites. These diseases and symptoms may include cancer, bacterial and viral infection, metabolic diseases such as Type II diabetes, NASH and NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis. Among the underlying mechanisms associated with the drug actions of niclosamide are uncoupling of oxidative phosphorylation, and modulation of Wnt/β-catenin, mTORC1, STAT3, NF-κB and Notch signaling pathways. Here we provide a brief overview of the biological activities of niclosamide, its potential clinical applications, and its challenges for use as a new therapy for systemic diseases.

Full Text

Duke Authors

Cited Authors

  • Chen, W; Mook, RA; Premont, RT; Wang, J

Published Date

  • January 2018

Published In

Volume / Issue

  • 41 /

Start / End Page

  • 89 - 96

PubMed ID

  • 28389414

Pubmed Central ID

  • 28389414

Electronic International Standard Serial Number (EISSN)

  • 1873-3913

Digital Object Identifier (DOI)

  • 10.1016/j.cellsig.2017.04.001

Language

  • eng

Conference Location

  • England