Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.

Journal Article (Journal Article)

Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para -hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei. Here we focus on the heteronuclear variant introduced as SABRE-SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) and nitrogen-15 targets in particular. We show that 15 N-SABRE works more efficiently and on a wider range of substrates than 1 H-SABRE, greatly generalizing the SABRE approach. In addition, we show that nitrogen-15 offers significantly extended T 1 times of up to 12 minutes. Long T 1 times enable higher hyperpolarization levels but also hold the promise of hyperpolarized molecular imaging for several tens of minutes. Detailed characterization and optimization are presented, leading to nitrogen-15 polarization levels in excess of 10% on several compounds.

Full Text

Duke Authors

Cited Authors

  • Colell, JFP; Logan, AWJ; Zhou, Z; Shchepin, RV; Barskiy, DA; Ortiz, GX; Wang, Q; Malcolmson, SJ; Chekmenev, EY; Warren, WS; Theis, T

Published Date

  • March 2017

Published In

Volume / Issue

  • 121 / 12

Start / End Page

  • 6626 - 6634

PubMed ID

  • 28392884

Pubmed Central ID

  • PMC5378067

Electronic International Standard Serial Number (EISSN)

  • 1932-7455

International Standard Serial Number (ISSN)

  • 1932-7447

Digital Object Identifier (DOI)

  • 10.1021/acs.jpcc.6b12097


  • eng