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Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.

Publication ,  Journal Article
Colell, JFP; Logan, AWJ; Zhou, Z; Shchepin, RV; Barskiy, DA; Ortiz, GX; Wang, Q; Malcolmson, SJ; Chekmenev, EY; Warren, WS; Theis, T
Published in: The journal of physical chemistry. C, Nanomaterials and interfaces
March 2017

Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para-hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei. Here we focus on the heteronuclear variant introduced as SABRE-SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) and nitrogen-15 targets in particular. We show that 15N-SABRE works more efficiently and on a wider range of substrates than 1H-SABRE, greatly generalizing the SABRE approach. In addition, we show that nitrogen-15 offers significantly extended T1 times of up to 12 minutes. Long T1 times enable higher hyperpolarization levels but also hold the promise of hyperpolarized molecular imaging for several tens of minutes. Detailed characterization and optimization are presented, leading to nitrogen-15 polarization levels in excess of 10% on several compounds.

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Published In

The journal of physical chemistry. C, Nanomaterials and interfaces

DOI

EISSN

1932-7455

ISSN

1932-7447

Publication Date

March 2017

Volume

121

Issue

12

Start / End Page

6626 / 6634

Related Subject Headings

  • Physical Chemistry
  • 40 Engineering
  • 34 Chemical sciences
  • 10 Technology
  • 09 Engineering
  • 03 Chemical Sciences
 

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Colell, J. F. P., Logan, A. W. J., Zhou, Z., Shchepin, R. V., Barskiy, D. A., Ortiz, G. X., … Theis, T. (2017). Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, 121(12), 6626–6634. https://doi.org/10.1021/acs.jpcc.6b12097
Colell, Johannes F. P., Angus W. J. Logan, Zijian Zhou, Roman V. Shchepin, Danila A. Barskiy, Gerardo X. Ortiz, Qiu Wang, et al. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.The Journal of Physical Chemistry. C, Nanomaterials and Interfaces 121, no. 12 (March 2017): 6626–34. https://doi.org/10.1021/acs.jpcc.6b12097.
Colell JFP, Logan AWJ, Zhou Z, Shchepin RV, Barskiy DA, Ortiz GX, et al. Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange. The journal of physical chemistry C, Nanomaterials and interfaces. 2017 Mar;121(12):6626–34.
Colell, Johannes F. P., et al. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, vol. 121, no. 12, Mar. 2017, pp. 6626–34. Epmc, doi:10.1021/acs.jpcc.6b12097.
Colell JFP, Logan AWJ, Zhou Z, Shchepin RV, Barskiy DA, Ortiz GX, Wang Q, Malcolmson SJ, Chekmenev EY, Warren WS, Theis T. Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange. The journal of physical chemistry C, Nanomaterials and interfaces. 2017 Mar;121(12):6626–6634.
Journal cover image

Published In

The journal of physical chemistry. C, Nanomaterials and interfaces

DOI

EISSN

1932-7455

ISSN

1932-7447

Publication Date

March 2017

Volume

121

Issue

12

Start / End Page

6626 / 6634

Related Subject Headings

  • Physical Chemistry
  • 40 Engineering
  • 34 Chemical sciences
  • 10 Technology
  • 09 Engineering
  • 03 Chemical Sciences