Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema.

Journal Article (Journal Article)

Swimming-induced pulmonary edema (SIPE) occurs during swimming and scuba diving, usually in cold water, in susceptible healthy individuals, especially military recruits and triathletes. We have previously demonstrated that pulmonary artery (PA) pressure and PA wedge pressure are higher during immersed exercise in SIPE-susceptible individuals versus controls, confirming that SIPE is a form of hemodynamic pulmonary edema. Oral sildenafil 50 mg 1 h before immersed exercise reduced PA pressure and PA wedge pressure, suggesting that sildenafil may prevent SIPE. We present a case of a 46-yr-old female ultratriathlete with a history of at least five SIPE episodes. During a study of an exercise submerged in 20°C water, physiological parameters before and after sildenafil 50 mg orally were as follows: O2 consumption 1.75, 1.76 L·min; HR 129, 135 bpm; arterial pressure 189/88 (mean 121.5), 172/85 (mean 114.3) mm Hg; mean PA pressure 35.3, 28.8 mm Hg; and PA wedge pressure 25.3, 19.7 mm Hg. She has had no recurrences during 20 subsequent triathlons while taking 50 mg sildenafil before each swim. This case supports sildenafil as an effective prophylactic agent against SIPE during competitive surface swimming.

Full Text

Duke Authors

Cited Authors

  • Martina, SD; Freiberger, JJ; Peacher, DF; Natoli, MJ; Schinazi, EA; Kernagis, DN; Potter, JVF; Otteni, CE; Moon, RE

Published Date

  • September 2017

Published In

Volume / Issue

  • 49 / 9

Start / End Page

  • 1755 - 1757

PubMed ID

  • 28398949

Electronic International Standard Serial Number (EISSN)

  • 1530-0315

Digital Object Identifier (DOI)

  • 10.1249/MSS.0000000000001293


  • eng

Conference Location

  • United States