Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.

Published

Journal Article

Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.

Full Text

Duke Authors

Cited Authors

  • Madden, DJ; Parks, EL; Tallman, CW; Boylan, MA; Hoagey, DA; Cocjin, SB; Packard, LE; Johnson, MA; Chou, Y-H; Potter, GG; Chen, N-K; Siciliano, RE; Monge, ZA; Honig, JA; Diaz, MT

Published Date

  • June 2017

Published In

Volume / Issue

  • 54 /

Start / End Page

  • 199 - 213

PubMed ID

  • 28389085

Pubmed Central ID

  • 28389085

Electronic International Standard Serial Number (EISSN)

  • 1558-1497

Digital Object Identifier (DOI)

  • 10.1016/j.neurobiolaging.2017.01.027

Language

  • eng

Conference Location

  • United States