Gleason Grading, Biochemical Failure, and Prostate Cancer-Specific Death.

Journal Article

Objectives: To examine the relationship between the recently defined Gleason grade groups and prostate cancer-specific mortality. Methods: If the probability of prostate cancer-specific death is symbolized as P(PSD), the probability of biochemical failure is symbolized as P(BF), and the probability of prostate cancer-specific death after biochemical failure is symbolized as P(PSD | BF), then the rules of probability provide a way to estimate P(PSD) as P(PSD) = P(PSD | BF) * P(BF) Using this model and data from the literature for P(PSD | BF) and P(BF), I estimate here values of P(PSD) for the five newly described Gleason grade groups. Results: The expected probability of prostate cancer- specific death is closely related to the new Gleason grade groups and ranges from a low of 0.014 for grade group 1 to a high of 0.15 for grade group 5. Conclusions: Although using the original study patient population may require years of additional follow-up to examine prostate cancer-specific mortality, the evidence available now indicates that these new Gleason grade groups relate to prostate cancer-specific mortality.

Full Text

Duke Authors

Cited Authors

  • Vollmer, RT

Published Date

  • March 1, 2017

Published In

Volume / Issue

  • 147 / 3

Start / End Page

  • 273 - 277

PubMed ID

  • 28395050

Pubmed Central ID

  • 28395050

Electronic International Standard Serial Number (EISSN)

  • 1943-7722

Digital Object Identifier (DOI)

  • 10.1093/ajcp/aqw212


  • eng

Conference Location

  • England