Ocular histopathology in Eastern equine encephalitis: A case report.

Published online

Journal Article

Purpose: To describe the ophthalmic symptoms and histopathological findings in a human case of Eastern equine encephalitis (EEE). Observations: The patient was a septuagenarian male whose presentation and clinical course were thought to be most consistent with viral meningoencephalitis. ELISA suggested recent infection with EEE virus. Microscopic analysis of the brain demonstrated perivascular lymphohistiocytic cuffing which was consistent with viral type encephalitis. Similarly, both eyes manifested a lymphohistiocytic infiltrate in the retina and optic nerve and a reduced number of ganglion cells. Conclusions and importance: To our knowledge, this is the first report of ophthalmological and ocular pathology observations in an EEE patient. Interestingly, the inflammatory findings in the retina are reminiscent of the central nervous system effects of EEE virus. These findings are relevant given the recent epidemic of microcephaly and ophthalmic complications secondary to another arboviral virus, the Zika virus.

Full Text

Duke Authors

Cited Authors

  • Lad, EM; Ong, SS; Proia, AD

Published Date

  • April 2017

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 99 - 102

PubMed ID

  • 29503959

Pubmed Central ID

  • 29503959

Electronic International Standard Serial Number (EISSN)

  • 2451-9936

Digital Object Identifier (DOI)

  • 10.1016/j.ajoc.2016.12.021


  • eng

Conference Location

  • United States