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Genetic determinants of adiponectin regulation revealed by pregnancy.

Publication ,  Journal Article
Hivert, M-F; Scholtens, DM; Allard, C; Nodzenski, M; Bouchard, L; Brisson, D; Lowe, LP; McDowell, I; Reddy, T; Dastani, Z; Richards, JB ...
Published in: Obesity (Silver Spring)
May 2017

OBJECTIVE: This study investigated genetic determinants of adiponectin during pregnancy to reveal novel biology of adipocyte regulation. METHODS: A genome-wide association study was conducted in 1,322 pregnant women from the Hyperglycemia and Adverse Pregnancy Outcome Study with adiponectin measured at ∼28 weeks of gestation. Variants reaching P < 5×10-5 for de novo genotyping in two replication cohorts (Genetics of Glycemic regulation in Gestation and Growth N = 522; ECOGENE-21 N = 174) were selected. RESULTS: In the combined meta-analysis, the maternal T allele of rs900400 located on chr3q25 (near LEKR1/CCNL1) was associated with lower maternal adiponectin (β ± standard error [SE] = -0.18 ± 0.03 standard deviation [SD] of adiponectin per risk allele; P = 1.5 ×10-8 ; N = 2,004; multivariable adjusted models). In contrast, rs900400 showed only nominal association with adiponectin in a large sample of nonpregnant women (β ± SE = -0.012 ± 0.006; P = 0.05; N = 16,678 women from the ADIPOgen consortium). The offspring rs900400 T risk allele was associated with greater neonatal skinfold thickness (β ±SE = 0.19 ± 0.04 SD per risk allele; P = 4.1×10-8 ; N = 1,489) and higher cord blood leptin (β ± SE = 0.28 ± 0.05 log-leptin per risk allele; P = 8.2 ×10-9 ; N = 502), but not with cord blood adiponectin (P = 0.23; N = 495). The T allele of rs900400 was associated with higher expression of TIPARP in adipocytes. CONCLUSIONS: These investigations of adipokines during pregnancy and early life suggest that rs900400 has a role in adipocyte function.

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Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

May 2017

Volume

25

Issue

5

Start / End Page

935 / 944

Location

United States

Related Subject Headings

  • Pregnancy
  • Humans
  • Genome-Wide Association Study
  • Female
  • Endocrinology & Metabolism
  • Cohort Studies
  • Adult
  • Adiponectin
 

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Hivert, M.-F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., … Lowe, W. L. (2017). Genetic determinants of adiponectin regulation revealed by pregnancy. Obesity (Silver Spring), 25(5), 935–944. https://doi.org/10.1002/oby.21805
Hivert, Marie-France, Denise M. Scholtens, Catherine Allard, Michael Nodzenski, Luigi Bouchard, Diane Brisson, Lynn P. Lowe, et al. “Genetic determinants of adiponectin regulation revealed by pregnancy.Obesity (Silver Spring) 25, no. 5 (May 2017): 935–44. https://doi.org/10.1002/oby.21805.
Hivert M-F, Scholtens DM, Allard C, Nodzenski M, Bouchard L, Brisson D, et al. Genetic determinants of adiponectin regulation revealed by pregnancy. Obesity (Silver Spring). 2017 May;25(5):935–44.
Hivert, Marie-France, et al. “Genetic determinants of adiponectin regulation revealed by pregnancy.Obesity (Silver Spring), vol. 25, no. 5, May 2017, pp. 935–44. Pubmed, doi:10.1002/oby.21805.
Hivert M-F, Scholtens DM, Allard C, Nodzenski M, Bouchard L, Brisson D, Lowe LP, McDowell I, Reddy T, Dastani Z, Richards JB, Hayes MG, Lowe WL. Genetic determinants of adiponectin regulation revealed by pregnancy. Obesity (Silver Spring). 2017 May;25(5):935–944.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

May 2017

Volume

25

Issue

5

Start / End Page

935 / 944

Location

United States

Related Subject Headings

  • Pregnancy
  • Humans
  • Genome-Wide Association Study
  • Female
  • Endocrinology & Metabolism
  • Cohort Studies
  • Adult
  • Adiponectin