Sleep and metabolism: role of hypothalamic neuronal circuitry.

Journal Article (Review;Journal Article)

Sleep and metabolism are intertwined physiologically and behaviorally, but the neural systems underlying their coordination are still poorly understood. The hypothalamus is likely to play a major role in the regulation sleep, metabolism, and their interaction. And increasing evidence suggests that hypocretin cells in the lateral hypothalamus may provide particularly important contributions. Here we review: 1) direct interactions between biological arousal and metabolic systems in the hypothalamus, and 2) indirect interactions between these two systems mediated by stress or reward, emphasizing the role of hypocretins. An increased understanding of the mechanisms underlying these interactions may provide novel approaches for the treatment of patients with sleep disorders and obesity, as well as suggest new therapeutic strategies for symptoms of aging, stress, or addiction.

Full Text

Duke Authors

Cited Authors

  • Rolls, A; Schaich Borg, J; de Lecea, L

Published Date

  • October 2010

Published In

Volume / Issue

  • 24 / 5

Start / End Page

  • 817 - 828

PubMed ID

  • 21112028

Electronic International Standard Serial Number (EISSN)

  • 1878-1594

International Standard Serial Number (ISSN)

  • 1521-690X

Digital Object Identifier (DOI)

  • 10.1016/j.beem.2010.08.002

Language

  • eng