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Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea.

Publication ,  Journal Article
Wang, T; Cai, H; Sasazuki, S; Tsugane, S; Zheng, W; Cho, ER; Jee, SH; Michel, A; Pawlita, M; Xiang, Y-B; Gao, Y-T; Shu, X-O; You, W-C; Epplein, M
Published in: Int J Cancer
February 1, 2017

Epidemiological findings on the association between fruit and vegetable consumption and gastric cancer risk remain inconsistent. The present analysis included 810 prospectively ascertained non-cardia gastric cancer cases and 1,160 matched controls from the Helicobacter pylori Biomarker Cohort Consortium, which collected blood samples, demographic, lifestyle, and dietary data at baseline. Conditional logistic regression adjusting for total energy intake, smoking, and H. pylori status, was applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for gastric cancer risk across cohort- and sex-specific quartiles of fruit and vegetable intake. Increasing fruit intake was associated with decreasing risk of non-cardia gastric cancer (OR = 0.71, 95% CI: 0.52-0.95, p trend = 0.02). Compared to low-fruit consumers infected with CagA-positive H. pylori, high-fruit consumers without evidence of H. pylori antibodies had the lowest odds for gastric cancer incidence (OR = 0.12, 95% CI: 0.06-0.25), whereby the inverse association with high-fruit consumption was attenuated among individuals infected with CagA-positive H. pylori (OR = 0.82, 95% CI: 0.66-1.03). To note, the small number of H. pylori negative individuals does influence this finding. We observed a weaker, nondose-response suggestion of an inverse association of vegetable intake with non-cardia gastric cancer risk. High fruit intake may play a role in decreasing risk of non-cardia gastric cancer in Asia.

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Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

February 1, 2017

Volume

140

Issue

3

Start / End Page

591 / 599

Location

United States

Related Subject Headings

  • Vegetables
  • Stomach Neoplasms
  • Risk Factors
  • Republic of Korea
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Logistic Models
  • Life Style
 

Citation

APA
Chicago
ICMJE
MLA
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Wang, T., Cai, H., Sasazuki, S., Tsugane, S., Zheng, W., Cho, E. R., … Epplein, M. (2017). Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea. Int J Cancer, 140(3), 591–599. https://doi.org/10.1002/ijc.30477
Wang, Tianyi, Hui Cai, Shizuka Sasazuki, Shoichiro Tsugane, Wei Zheng, Eo Rin Cho, Sun Ha Jee, et al. “Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea.Int J Cancer 140, no. 3 (February 1, 2017): 591–99. https://doi.org/10.1002/ijc.30477.
Wang, Tianyi, et al. “Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea.Int J Cancer, vol. 140, no. 3, Feb. 2017, pp. 591–99. Pubmed, doi:10.1002/ijc.30477.
Wang T, Cai H, Sasazuki S, Tsugane S, Zheng W, Cho ER, Jee SH, Michel A, Pawlita M, Xiang Y-B, Gao Y-T, Shu X-O, You W-C, Epplein M. Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea. Int J Cancer. 2017 Feb 1;140(3):591–599.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

February 1, 2017

Volume

140

Issue

3

Start / End Page

591 / 599

Location

United States

Related Subject Headings

  • Vegetables
  • Stomach Neoplasms
  • Risk Factors
  • Republic of Korea
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Logistic Models
  • Life Style