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Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men.

Publication ,  Journal Article
Epplein, M; Zheng, W; Li, H; Peek, RM; Correa, P; Gao, J; Michel, A; Pawlita, M; Cai, Q; Xiang, Y-B; Shu, X-O
Published in: Nutr Cancer
2014

Evidence for the association of diet and gastric cancer is equivocal, and the majority of previous studies have not evaluated the interaction of diet and infection with Helicobacter pylori, the leading risk factor for gastric cancer. We examined these associations among 226 cases and 451 controls nested within a prospective cohort. Dietary intakes were calculated from validated food frequency questionnaires. Blood levels of 15 antibodies to Helicobacter pylori proteins were assessed using multiplex serology. Odds ratios (ORs) were calculated using logistic regression. Among individuals infected with high-risk Helicobacter pylori (sero-positivity to 5-6 virulent H. pylori proteins), increasing intake of red meat, heme iron, and sodium increased risk (comparing highest tertile to lowest: ORs [95% confidence interval {CI}]: 1.85 [1.01-3.40]; 1.95 [1.06-3.57]; and 1.76 [0.91-3.43], respectively) while increasing intake of fruit decreased gastric cancer risk (comparing highest tertile of intake to lowest: OR [95% CI]: 0.52 [0.28-0.94]). No associations of diet with risk were found among individuals infected with low-risk H. pylori (P for interaction for red meat and sodium: 0.02 and 0.01, respectively). In this population with over 90% prevalence of CagA-positive H. pylori infection, categorizing individuals using H. pylori multiplex serology may identify individuals for whom a diet intervention may be effective.

Duke Scholars

Published In

Nutr Cancer

DOI

EISSN

1532-7914

Publication Date

2014

Volume

66

Issue

4

Start / End Page

550 / 557

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Stomach
  • Risk Factors
  • Prospective Studies
  • Nutrition & Dietetics
  • Middle Aged
  • Meat
  • Male
  • Logistic Models
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Epplein, M., Zheng, W., Li, H., Peek, R. M., Correa, P., Gao, J., … Shu, X.-O. (2014). Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Nutr Cancer, 66(4), 550–557. https://doi.org/10.1080/01635581.2014.894096
Epplein, Meira, Wei Zheng, Honglan Li, Richard M. Peek, Pelayo Correa, Jing Gao, Angelika Michel, et al. “Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men.Nutr Cancer 66, no. 4 (2014): 550–57. https://doi.org/10.1080/01635581.2014.894096.
Epplein M, Zheng W, Li H, Peek RM, Correa P, Gao J, et al. Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Nutr Cancer. 2014;66(4):550–7.
Epplein, Meira, et al. “Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men.Nutr Cancer, vol. 66, no. 4, 2014, pp. 550–57. Pubmed, doi:10.1080/01635581.2014.894096.
Epplein M, Zheng W, Li H, Peek RM, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Xiang Y-B, Shu X-O. Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Nutr Cancer. 2014;66(4):550–557.

Published In

Nutr Cancer

DOI

EISSN

1532-7914

Publication Date

2014

Volume

66

Issue

4

Start / End Page

550 / 557

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Stomach
  • Risk Factors
  • Prospective Studies
  • Nutrition & Dietetics
  • Middle Aged
  • Meat
  • Male
  • Logistic Models
  • Humans