Gastric cancer: an infectious disease.

Journal Article (Journal Article;Review)

The role of infectious agents and chronic inflammation in carcinogenesis is being increasingly recognized. It has been estimated that about 18% of cancers are directly linked to infections, particularly gastric adenocarcinoma (Helicobacter pylori), cervical carcinoma (human papilloma viruses), and hepatocarcinoma (hepatitis B and C viruses). Multiple clinical trials of COX-2 inhibitors and other antiinflammatory agents have shown a beneficial effect on the development of diverse tumors, such as those of the colon, stomach, prostate, and breast. However, their mechanism of action is not completely understood and may differ among the infectious agents and tumor types. Because gastric adenocarcinomas account for more than 90% of all gastric malignancies, this review focuses on adenocarcinomas.

Full Text

Duke Authors

Cited Authors

  • Piazuelo, MB; Epplein, M; Correa, P

Published Date

  • December 2010

Published In

Volume / Issue

  • 24 / 4

Start / End Page

  • 853 - vii

PubMed ID

  • 20937454

Pubmed Central ID

  • PMC2954127

Electronic International Standard Serial Number (EISSN)

  • 1557-9824

Digital Object Identifier (DOI)

  • 10.1016/j.idc.2010.07.010


  • eng

Conference Location

  • United States