Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history.

Journal Article (Journal Article)

The authors sought to test the hypothesis that characteristics and exposures which influence the balance of estrogen and progesterone bear on the incidence of endometrial hyperplasia (EH), a noninvasive proliferation of the lining of the uterus. Cases included all female members of Group Health (Washington State) who were diagnosed with complex EH or EH with atypia during the period 1985-2003 and whose diagnoses were confirmed in a pathology review (n = 446). Controls were selected randomly from Group Health membership files and were matched to the cases by age and enrollment status at the reference date. An increased risk of EH was associated with increasing body mass index and nulliparity. There was a suggestion of a decreased risk of EH with atypia among current smokers. No association with diabetes or hypertension was found. The risk factors observed to be associated with EH in this study are similar to those associated with endometrial cancer. Whether these risk factors predispose women to cancer simply by increasing EH incidence or continue to augment cancer risk even after EH is present is currently unknown.

Full Text

Duke Authors

Cited Authors

  • Epplein, M; Reed, SD; Voigt, LF; Newton, KM; Holt, VL; Weiss, NS

Published Date

  • September 15, 2008

Published In

Volume / Issue

  • 168 / 6

Start / End Page

  • 563 - 570

PubMed ID

  • 18682485

Pubmed Central ID

  • PMC2727194

Electronic International Standard Serial Number (EISSN)

  • 1476-6256

Digital Object Identifier (DOI)

  • 10.1093/aje/kwn168


  • eng

Conference Location

  • United States