Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii.

Journal Article (Journal Article)

OBJECTIVE: The risk factors most strongly associated with gastric cancer are the gastric bacteria Helicobacter pylori and diet. Utilizing data from a case-control study among residents in Hawaii, we examined the association of diet, presence of H. pylori, and non-cardia gastric cancer risk. METHODS: Serum taken at diagnosis for cases (n = 212) and at interview for controls (n = 336) was assayed for IgG antibodies to H. pylori group antigens and to a recombinant fragment of the cytotoxin-associated antigen A (CagA) protein, and subjects completed food frequency questionnaires. Risk measures were calculated using logistic regression. The likelihood ratio test was used to assess interactions. RESULTS: Inverse associations were found between gastric cancer risk and increasing intake of several micronutrients and vegetables among all individuals. For H. pylori/CagA-positive subjects, significant trends were present for total, green, and yellow vegetables, while a significant trend was present only for yellow vegetables among H. pylori/CagA-negative individuals. For intestinal gastric cancer, there was a suggestion that intake of vegetables, especially cruciferous vegetables, had a stronger protective effect for the H. pylori/CagA-positive group. CONCLUSIONS: Diet may play a greater role in the etiology of non-cardia gastric cancer among individuals with evidence of H. pylori infection than among those without.

Full Text

Duke Authors

Cited Authors

  • Epplein, M; Nomura, AMY; Hankin, JH; Blaser, MJ; Perez-Perez, G; Stemmermann, GN; Wilkens, LR; Kolonel, LN

Published Date

  • October 2008

Published In

Volume / Issue

  • 19 / 8

Start / End Page

  • 869 - 877

PubMed ID

  • 18369531

Pubmed Central ID

  • PMC2799111

Electronic International Standard Serial Number (EISSN)

  • 1573-7225

Digital Object Identifier (DOI)

  • 10.1007/s10552-008-9149-2


  • eng

Conference Location

  • Netherlands