A sister's risk: family history as a predictor of preeclampsia.

Journal Article

OBJECTIVE: The purpose of this study was to determine if women with preeclampsia are more likely to have a sister who also had preeclampsia. STUDY DESIGN: This was a population-based case-control study using data from Washington (WA) state birth certificates linked to hospital discharge records. Cases were women with gestational hypertension (n = 1611) or preeclampsia (n = 1071); controls (n = 8041) had normotensive pregnancies. All women delivered their first child between 1987 to 2002 and had a sister with a previous delivery in WA. RESULTS: Women with preeclampsia were 2.3 times (95%CI 1.8-2.9) more likely to have a sister who had preeclampsia; those with gestational hypertension were 1.6 times (95%CI 1.3-2.0) more likely to have a sister with gestational hypertension. Similar results were obtained following stratification by age, race, smoking status, or body mass index. CONCLUSION: The greater likelihood of preeclampsia among sisters of women with a previous preeclamptic pregnancy is consistent with a pathophysiologic role for genetic and/or behavioral factors that cluster in families.

Full Text

Duke Authors

Cited Authors

  • Carr, DB; Epplein, M; Johnson, CO; Easterling, TR; Critchlow, CW

Published Date

  • September 2005

Published In

Volume / Issue

  • 193 / 3 Pt 2

Start / End Page

  • 965 - 972

PubMed ID

  • 16157095

Pubmed Central ID

  • 16157095

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2005.06.034


  • eng

Conference Location

  • United States