Metal ion levels in maternal and placental blood after metal-on-metal total hip arthroplasty.

Journal Article (Journal Article)

There is concern regarding elevated metal ion levels in the blood during pregnancy and the potential fetal effects in women with metal-on-metal (MOM) implants. We obtained maternal and umbilical cord blood samples from 3 patients with a MOM hip arthroplasty and 7 control subjects without any metallic implants. Serum metal ion levels including chromium, cobalt, titanium, and nickel were tested using high-resolution sector-field inductively-coupled plasma-mass spectrometry. Mothers with MOM-bearing implants had significantly elevated levels of serum cobalt and chromium compared with control-group mothers, and umbilical cord blood from mothers with MOM implants also had significantly higher serum metal ion levels compared with control-group mothers. The results of this study show that circulating serum levels of metal ion degradation products from MOM bearings cross the placenta and expose the fetus to metal ions. However, the placenta exerts a modulatory effect on cord blood, resulting in decreased levels compared with maternal samples (approximately 15% of maternal chromium and 50% of maternal cobalt). Physicians and women of child-bearing age should be aware of this potential effect when considering the use of MOM-bearing implants.

Full Text

Duke Authors

Cited Authors

  • Novak, CC; Hsu, AR; Della Valle, CJ; Skipor, AK; Campbell, P; Amstutz, HC; Jiranek, WA; Onyike, A; Pombar, XF; Jacobs, JJ

Published Date

  • December 2014

Published In

Volume / Issue

  • 43 / 12

Start / End Page

  • E304 - E308

PubMed ID

  • 25490017

Electronic International Standard Serial Number (EISSN)

  • 1934-3418


  • eng

Conference Location

  • United States