Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement.

Published

Journal Article (Review)

Use of antibiotic-loaded bone cement for prophylaxis against infection is not indicated for patients not at high risk for infection who are undergoing routine primary or revision joint replacement with cement. The mechanical and elution properties of commercially available premixed antibiotic-loaded bone-cement products are superior to those of hand-mixed preparations. Use of commercially available antibiotic-loaded bone-cement products has been cleared by the United States Food and Drug Administration only for use in the second stage of a two-stage total joint revision following removal of the original prosthesis and elimination of active periprosthetic infection. Use of antibiotic-loaded bone cement for prophylaxis against infection in the second stage of a two-stage total joint revision involves low doses of antibiotics. Active infection cannot be treated with commercially available antibiotic-loaded bone cement as such treatment requires higher doses of antibiotics.

Full Text

Duke Authors

Cited Authors

  • Jiranek, WA; Hanssen, AD; Greenwald, AS

Published Date

  • November 2006

Published In

Volume / Issue

  • 88 / 11

Start / End Page

  • 2487 - 2500

PubMed ID

  • 17079409

Pubmed Central ID

  • 17079409

International Standard Serial Number (ISSN)

  • 0021-9355

Digital Object Identifier (DOI)

  • 10.2106/JBJS.E.01126

Language

  • eng

Conference Location

  • United States