Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase.

Published

Journal Article

The synthesis of a library of nucleoside triphosphate mimetics is described where the Mg(2+) chelated triphosphate sidechain is replaced by an uncharged methylene-triazole linked monosaccharide sidechain. The compounds have been evaluated as inhibitors of Bacillus anthracis pantothenate kinase and a competitive inhibitor has been identified with a K(i) that is 3-fold lower than the K(m) value of ATP.

Full Text

Cited Authors

  • Rowan, AS; Nicely, NI; Cochrane, N; Wlassoff, WA; Claiborne, A; Hamilton, CJ

Published Date

  • October 2009

Published In

Volume / Issue

  • 7 / 19

Start / End Page

  • 4029 - 4036

PubMed ID

  • 19763307

Pubmed Central ID

  • 19763307

Electronic International Standard Serial Number (EISSN)

  • 1477-0539

International Standard Serial Number (ISSN)

  • 1477-0520

Digital Object Identifier (DOI)

  • 10.1039/b909729e

Language

  • eng