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Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.

Publication ,  Journal Article
Toth, GB; Varallyay, CG; Horvath, A; Bashir, MR; Choyke, PL; Daldrup-Link, HE; Dosa, E; Finn, JP; Gahramanov, S; Harisinghani, M; Macdougall, I ...
Published in: Kidney Int
July 2017

Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool. Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG Pharmaceuticals, Waltham, MA), used as an alternative contrast medium, is feasible in patients with impaired renal function. Other attractive imaging features of i.v. ferumoxytol include a prolonged blood pool phase and delayed intracellular uptake. With its unique pharmacologic, metabolic, and imaging properties, ferumoxytol may play a crucial role in future magnetic resonance imaging of the central nervous system, various organs outside the central nervous system, and the cardiovascular system. Preclinical and clinical studies have demonstrated the overall safety and effectiveness of this novel contrast agent, with rarely occurring anaphylactoid reactions. The purpose of this review is to describe the general and organ-specific properties of ferumoxytol, as well as the advantages and potential pitfalls associated with its use in magnetic resonance imaging. To more fully demonstrate the applications of ferumoxytol throughout the body, an imaging atlas was created and is available online as supplementary material.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

July 2017

Volume

92

Issue

1

Start / End Page

47 / 66

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Reproducibility of Results
  • Renal Insufficiency, Chronic
  • Renal Elimination
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Kidney
  • Humans
 

Citation

APA
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Toth, G. B., Varallyay, C. G., Horvath, A., Bashir, M. R., Choyke, P. L., Daldrup-Link, H. E., … Neuwelt, E. A. (2017). Current and potential imaging applications of ferumoxytol for magnetic resonance imaging. Kidney Int, 92(1), 47–66. https://doi.org/10.1016/j.kint.2016.12.037
Toth, Gerda B., Csanad G. Varallyay, Andrea Horvath, Mustafa R. Bashir, Peter L. Choyke, Heike E. Daldrup-Link, Edit Dosa, et al. “Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.Kidney Int 92, no. 1 (July 2017): 47–66. https://doi.org/10.1016/j.kint.2016.12.037.
Toth GB, Varallyay CG, Horvath A, Bashir MR, Choyke PL, Daldrup-Link HE, et al. Current and potential imaging applications of ferumoxytol for magnetic resonance imaging. Kidney Int. 2017 Jul;92(1):47–66.
Toth, Gerda B., et al. “Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.Kidney Int, vol. 92, no. 1, July 2017, pp. 47–66. Pubmed, doi:10.1016/j.kint.2016.12.037.
Toth GB, Varallyay CG, Horvath A, Bashir MR, Choyke PL, Daldrup-Link HE, Dosa E, Finn JP, Gahramanov S, Harisinghani M, Macdougall I, Neuwelt A, Vasanawala SS, Ambady P, Barajas R, Cetas JS, Ciporen J, DeLoughery TJ, Doolittle ND, Fu R, Grinstead J, Guimaraes AR, Hamilton BE, Li X, McConnell HL, Muldoon LL, Nesbit G, Netto JP, Petterson D, Rooney WD, Schwartz D, Szidonya L, Neuwelt EA. Current and potential imaging applications of ferumoxytol for magnetic resonance imaging. Kidney Int. 2017 Jul;92(1):47–66.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

July 2017

Volume

92

Issue

1

Start / End Page

47 / 66

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Reproducibility of Results
  • Renal Insufficiency, Chronic
  • Renal Elimination
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Kidney
  • Humans