Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.

Journal Article

Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT pathway was the most frequently mutated pathway, with frequent mutations in STAT5B as well as JAK1, JAK3, STAT3, and SOCS1 We also identified mutations in KRAS, TP53, and TERT Type I EATL and type II EATL (monomorphic epitheliotropic intestinal T cell lymphoma) had highly overlapping genetic alterations indicating shared mechanisms underlying their pathogenesis. We modeled the effects of SETD2 loss in vivo by developing a T cell-specific knockout mouse. These mice manifested an expansion of γδ T cells, indicating novel roles for SETD2 in T cell development and lymphomagenesis. Our data render the most comprehensive genetic portrait yet of this uncommon but lethal disease and may inform future classification schemes.

Full Text

Duke Authors

Cited Authors

  • Moffitt, AB; Ondrejka, SL; McKinney, M; Rempel, RE; Goodlad, JR; Teh, CH; Leppa, S; Mannisto, S; Kovanen, PE; Tse, E; Au-Yeung, RKH; Kwong, Y-L; Srivastava, G; Iqbal, J; Yu, J; Naresh, K; Villa, D; Gascoyne, RD; Said, J; Czader, MB; Chadburn, A; Richards, KL; Rajagopalan, D; Davis, NS; Smith, EC; Palus, BC; Tzeng, TJ; Healy, JA; Lugar, PL; Datta, J; Love, C; Levy, S; Dunson, DB; Zhuang, Y; Hsi, ED; Dave, SS

Published Date

  • May 2017

Published In

Volume / Issue

  • 214 / 5

Start / End Page

  • 1371 - 1386

PubMed ID

  • 28424246

Electronic International Standard Serial Number (EISSN)

  • 1540-9538

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20160894

Language

  • eng