Today's Approach to Treating Brain Swelling in the Neuro Intensive Care Unit.
Journal Article (Journal Article;Review)
Brain swelling is an urgent clinical problem that frequently accompanies ischemic stroke, brain hemorrhage, and traumatic brain injury; it increases morbidity and mortality associated with them. It occurs due to failure of membrane transporters and leakage of the blood-brain barrier (BBB), resulting in combination of cytotoxic, ionic, and vasogenic edema. Currently, decompressive craniectomy and osmotherapy are the mainstays of management, but these therapies do not halt the underlying molecular cascade leading to brain swelling. Recent advances in the molecular underpinnings of cerebral edema have opened up possibilities of newer targeted therapeutic options. Here the authors outline the current approach for rapid diagnosis and intervention to reduce mortality and morbidity associated with brain swelling.
Full Text
Duke Authors
Cited Authors
- Shah, S; Kimberly, WT
Published Date
- December 2016
Published In
Volume / Issue
- 36 / 6
Start / End Page
- 502 - 507
PubMed ID
- 27907954
Pubmed Central ID
- PMC5319198
Electronic International Standard Serial Number (EISSN)
- 1098-9021
Digital Object Identifier (DOI)
- 10.1055/s-0036-1592109
Language
- eng
Conference Location
- United States