Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells


Journal Article

© 2017 Elsevier Ltd Obtaining accurate temperature distributions in living tissue related to hyperthermia skin cancer treatment without using an intruding sensor is a challenge. Here, we report a mathematical model that can accurately determine the temperature distribution in the tumor region and surrounding normal tissue. The model is based on a modified Pennes’ equation for the bioheat transfer in a 3-D triple-layered skin structure embedded with a vascular countercurrent network and a tumor appearing in the subcutaneous region. The vascular network is designed based on the constructal theory of multi-scale tree-shaped heat exchangers. The tumor is injected with gold nanoshells in order to be heated quickly. The proposed model is implemented numerically using a stable finite difference scheme. The method is demonstrated and tested by an example.

Full Text

Duke Authors

Cited Authors

  • Orndorff, C; Ponomarev, S; Dai, W; Bejan, A

Published Date

  • January 1, 2017

Published In

Volume / Issue

  • 111 /

Start / End Page

  • 677 - 695

International Standard Serial Number (ISSN)

  • 0017-9310

Digital Object Identifier (DOI)

  • 10.1016/j.ijheatmasstransfer.2017.04.024

Citation Source

  • Scopus