Ordinary Differential Equation Models for Adoptive Immunotherapy.

Published

Journal Article

Modified T cells that have been engineered to recognize the CD19 surface marker have recently been shown to be very successful at treating acute lymphocytic leukemias. Here, we explore four previous approaches that have used ordinary differential equations to model this type of therapy, compare their properties, and modify the models to address their deficiencies. Although the four models treat the workings of the immune system in slightly different ways, they all predict that adoptive immunotherapy can be successful to move a patient from the large tumor fixed point to an equilibrium with little or no tumor.

Full Text

Duke Authors

Cited Authors

  • Talkington, A; Dantoin, C; Durrett, R

Published Date

  • May 2018

Published In

Volume / Issue

  • 80 / 5

Start / End Page

  • 1059 - 1083

PubMed ID

  • 28382423

Pubmed Central ID

  • 28382423

Electronic International Standard Serial Number (EISSN)

  • 1522-9602

International Standard Serial Number (ISSN)

  • 0092-8240

Digital Object Identifier (DOI)

  • 10.1007/s11538-017-0263-8

Language

  • eng