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Is aspirin associated with diabetic retinopathy? The Singapore Epidemiology of Eye Disease (SEED) study.

Publication ,  Journal Article
Shi, Y; Tham, Y-C; Cheung, N; Chua, J; Tan, G; Mitchell, P; Wang, JJ; Cheung, YB; Cheng, C-Y; Wong, TY
Published in: PLoS One
2017

BACKGROUND/AIMS: To determine the association between aspirin use and diabetic retinopathy (DR) among persons with diabetes, in a population-based, cross-sectional study. METHODS: Subjects with diabetes aged >40 years from the Singapore Epidemiology of Eye Diseases Study were enrolled in this study. Retinal photographs were graded for DR according to the modified Airlie House classification system. Vision threatening diabetic retinopathy (VTDR) was defined as the presence of severe non-proliferative DR, or proliferative DR, or clinically significant macular oedema. The association between aspirin use and the presence of DR or VTDR was assessed using multivariable logistic regression models including age, gender, ethnicity, socioeconomic status, HbA1c, systolic blood pressure, anti-hypertension medicine, total cholesterol, anti-cholesterol medicine, BMI, current smoking status, diabetes duration, history of cardiovascular disease (CVD) and chronic kidney disease (CKD.). RESULTS: A total of 2,061 participants with diabetes and complete record of relevant systemic and DR data were included. Of these, 711 (34.5%) had any stage of DR, and among these 177 (8.6%) had VTDR. After adjusting for co-variables listed, the association between aspirin use and VTDR was significant (OR = 1.69, P = 0.019), while the association between aspirin use and any DR was borderline (OR = 1.31, P = 0.063). Aspirin use was not associated with either DR or VTDR after additional adjustment of CVD and CKD. Further stratification by history of CVD or CKD showed no association between aspirin use and DR/VTDR in either subgroup. CONCLUSION: Aspirin use was not significantly associated with DR but might be an indicator of diabetic complications (CVD, CKD) that were co-present with more severe DR type. Future longitudinal studies are warranted to confirm our findings.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

4

Start / End Page

e0175966

Location

United States

Related Subject Headings

  • Singapore
  • Regression Analysis
  • Middle Aged
  • Male
  • Humans
  • General Science & Technology
  • Female
  • Diabetic Retinopathy
  • Aspirin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shi, Y., Tham, Y.-C., Cheung, N., Chua, J., Tan, G., Mitchell, P., … Wong, T. Y. (2017). Is aspirin associated with diabetic retinopathy? The Singapore Epidemiology of Eye Disease (SEED) study. PLoS One, 12(4), e0175966. https://doi.org/10.1371/journal.pone.0175966
Shi, Yuan, Yih-Chung Tham, Ning Cheung, Jacqueline Chua, Gavin Tan, Paul Mitchell, Jie Jin Wang, Yin Bun Cheung, Ching-Yu Cheng, and Tien Yin Wong. “Is aspirin associated with diabetic retinopathy? The Singapore Epidemiology of Eye Disease (SEED) study.PLoS One 12, no. 4 (2017): e0175966. https://doi.org/10.1371/journal.pone.0175966.
Shi Y, Tham Y-C, Cheung N, Chua J, Tan G, Mitchell P, et al. Is aspirin associated with diabetic retinopathy? The Singapore Epidemiology of Eye Disease (SEED) study. PLoS One. 2017;12(4):e0175966.
Shi, Yuan, et al. “Is aspirin associated with diabetic retinopathy? The Singapore Epidemiology of Eye Disease (SEED) study.PLoS One, vol. 12, no. 4, 2017, p. e0175966. Pubmed, doi:10.1371/journal.pone.0175966.
Shi Y, Tham Y-C, Cheung N, Chua J, Tan G, Mitchell P, Wang JJ, Cheung YB, Cheng C-Y, Wong TY. Is aspirin associated with diabetic retinopathy? The Singapore Epidemiology of Eye Disease (SEED) study. PLoS One. 2017;12(4):e0175966.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

4

Start / End Page

e0175966

Location

United States

Related Subject Headings

  • Singapore
  • Regression Analysis
  • Middle Aged
  • Male
  • Humans
  • General Science & Technology
  • Female
  • Diabetic Retinopathy
  • Aspirin