Dysfunctional T cell metabolism in the tumor microenvironment.


Journal Article (Review)

Metabolic and signaling pathways are integrated to determine T cell fate and function. As stimulated T cells gain distinct effector functions, specific metabolic programs and demands are also adopted. These changes are essential for T cell effector function, and alterations or dysregulation of metabolic pathways can modulate T cell function. One physiological setting that impacts T cell metabolism is the tumor microenvironment. The metabolism of cancer cells themselves can limit nutrients and accumulate waste products. In addition to the expression of inhibitory ligands that directly modify T cell physiology, T cell metabolism may be strongly inhibited in the tumor microenvironment. This suppression of T cell metabolism may inhibit effector T cell activity while promoting suppressive regulatory T cells, and act as a barrier to effective immunotherapies. A thorough understanding of the effect of the tumor microenvironment on the immune system will support the continued improvement of immune based therapies for cancer patients.

Full Text

Duke Authors

Cited Authors

  • Beckermann, KE; Dudzinski, SO; Rathmell, JC

Published Date

  • June 2017

Published In

Volume / Issue

  • 35 /

Start / End Page

  • 7 - 14

PubMed ID

  • 28456467

Pubmed Central ID

  • 28456467

Electronic International Standard Serial Number (EISSN)

  • 1879-0305

Digital Object Identifier (DOI)

  • 10.1016/j.cytogfr.2017.04.003


  • eng

Conference Location

  • England