A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities.

Journal Article (Journal Article)

BACKGROUND: To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration. METHODS: We surveyed investigators from North America, Europe, and Australia about existing JIA cohort studies and registries. We excluded cross-sectional studies. We captured information about study design, duration, location, inclusion criteria, data elements and collection methods. RESULTS: We received survey results from 18 studies, including 11 national and 7 multi-national studies representing 37 countries in total. Study designs included inception cohorts, prevalent disease cohorts, and new treatment cohorts (several of which contribute to pharmacosurveillance activities). Despite numerous differences, the data elements collected across the studies was quite similar, with most studies collecting at least 5 of the 6 American College of Rheumatology core set variables and the data needed to calculate the 3-variable clinical juvenile disease activity score. Most studies were collecting medication initiation and discontinuation dates and were attempting to capture serious adverse events. CONCLUSION: There is a wide-range of large, ongoing JIA registries and cohort studies around the world. Our survey results indicate significant potential for future collaborative work using data from different studies and both combined and comparative analyses.

Full Text

Duke Authors

Cited Authors

  • Beukelman, T; Anink, J; Berntson, L; Duffy, C; Ellis, JA; Glerup, M; Guzman, J; Horneff, G; Kearsley-Fleet, L; Klein, A; Klotsche, J; Magnusson, B; Minden, K; Munro, JE; Niewerth, M; Nordal, E; Ruperto, N; Santos, MJ; Schanberg, LE; Thomson, W; van Suijlekom-Smit, L; Wulffraat, N; Hyrich, K

Published Date

  • April 19, 2017

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 31 -

PubMed ID

  • 28424093

Pubmed Central ID

  • PMC5395903

Electronic International Standard Serial Number (EISSN)

  • 1546-0096

Digital Object Identifier (DOI)

  • 10.1186/s12969-017-0161-5


  • eng

Conference Location

  • England