Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange.

Journal Article (Journal Article)

Signal amplification by reversible exchange (SABRE) is an inexpensive, fast, and even continuous hyperpolarization technique that uses para-hydrogen as hyperpolarization source. However, current SABRE faces a number of stumbling blocks for translation to biochemical and clinical settings. Difficulties include inefficient polarization in water, relatively short-lived 1 H-polarization, and relatively limited substrate scope. Here we use a water-soluble polarization transfer catalyst to hyperpolarize nitrogen-15 in a variety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei). This strategy works in pure H2 O or D2 O solutions, on substrates that could not be hyperpolarized in traditional 1 H-SABRE experiments, and we record 15 N T1 relaxation times of up to 2 min.

Full Text

Duke Authors

Cited Authors

  • Colell, JFP; Emondts, M; Logan, AWJ; Shen, K; Bae, J; Shchepin, RV; Ortiz, GX; Spannring, P; Wang, Q; Malcolmson, SJ; Chekmenev, EY; Feiters, MC; Rutjes, FPJT; Blümich, B; Theis, T; Warren, WS

Published Date

  • June 2017

Published In

Volume / Issue

  • 139 / 23

Start / End Page

  • 7761 - 7767

PubMed ID

  • 28443329

Pubmed Central ID

  • PMC5578426

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/jacs.7b00569


  • eng