Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus.


Journal Article

We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine samples. MIF/creatinine (Cr) ratio directly correlated with disease activity and it does not have any significant difference between inactive disease and normal ones. We found that the urine MIF/Cr ratio not only differentiates active disease from inactive disease and normal ones but also correlates with the activity indices of renal pathology.

Full Text

Duke Authors

Cited Authors

  • Otukesh, H; Chalian, M; Hoseini, R; Chalian, H; Hooman, N; Bedayat, A; Yazdi, RS; Sabaghi, S; Mahdavi, S

Published Date

  • December 2007

Published In

Volume / Issue

  • 26 / 12

Start / End Page

  • 2105 - 2107

PubMed ID

  • 17479310

Pubmed Central ID

  • 17479310

International Standard Serial Number (ISSN)

  • 0770-3198

Digital Object Identifier (DOI)

  • 10.1007/s10067-007-0632-z


  • eng

Conference Location

  • Germany