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How and why do T cells and their derived cytokines affect the injured and healthy brain?

Publication ,  Journal Article
Filiano, AJ; Gadani, SP; Kipnis, J
Published in: Nat Rev Neurosci
June 2017

The evolution of adaptive immunity provides enhanced defence against specific pathogens, as well as homeostatic immune surveillance of all tissues. Despite being 'immune privileged', the CNS uses the assistance of the immune system in physiological and pathological states. In this Opinion article, we discuss the influence of adaptive immunity on recovery after CNS injury and on cognitive and social brain function. We further extend a hypothesis that the pro-social effects of interferon-regulated genes were initially exploited by pathogens to increase host-host transmission, and that these genes were later recycled by the host to form part of an immune defence programme. In this way, the evolution of adaptive immunity may reflect a host-pathogen 'arms race'.

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Published In

Nat Rev Neurosci

DOI

EISSN

1471-0048

Publication Date

June 2017

Volume

18

Issue

6

Start / End Page

375 / 384

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Neurology & Neurosurgery
  • Humans
  • Cytokines
  • Brain Injuries, Traumatic
  • Brain Injuries
  • Brain
  • Animals
  • Adaptive Immunity
  • 5202 Biological psychology
 

Citation

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Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017). How and why do T cells and their derived cytokines affect the injured and healthy brain? Nat Rev Neurosci, 18(6), 375–384. https://doi.org/10.1038/nrn.2017.39
Filiano, Anthony J., Sachin P. Gadani, and Jonathan Kipnis. “How and why do T cells and their derived cytokines affect the injured and healthy brain?Nat Rev Neurosci 18, no. 6 (June 2017): 375–84. https://doi.org/10.1038/nrn.2017.39.
Filiano AJ, Gadani SP, Kipnis J. How and why do T cells and their derived cytokines affect the injured and healthy brain? Nat Rev Neurosci. 2017 Jun;18(6):375–84.
Filiano, Anthony J., et al. “How and why do T cells and their derived cytokines affect the injured and healthy brain?Nat Rev Neurosci, vol. 18, no. 6, June 2017, pp. 375–84. Pubmed, doi:10.1038/nrn.2017.39.
Filiano AJ, Gadani SP, Kipnis J. How and why do T cells and their derived cytokines affect the injured and healthy brain? Nat Rev Neurosci. 2017 Jun;18(6):375–384.

Published In

Nat Rev Neurosci

DOI

EISSN

1471-0048

Publication Date

June 2017

Volume

18

Issue

6

Start / End Page

375 / 384

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Neurology & Neurosurgery
  • Humans
  • Cytokines
  • Brain Injuries, Traumatic
  • Brain Injuries
  • Brain
  • Animals
  • Adaptive Immunity
  • 5202 Biological psychology