Major review: Molecular genetics of primary open-angle glaucoma.

Journal Article (Journal Article;Review)

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.

Full Text

Duke Authors

Cited Authors

  • Liu, Y; Allingham, RR

Published Date

  • July 2017

Published In

Volume / Issue

  • 160 /

Start / End Page

  • 62 - 84

PubMed ID

  • 28499933

Pubmed Central ID

  • PMC5557663

Electronic International Standard Serial Number (EISSN)

  • 1096-0007

Digital Object Identifier (DOI)

  • 10.1016/j.exer.2017.05.002


  • eng

Conference Location

  • England