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Major review: Molecular genetics of primary open-angle glaucoma.

Publication ,  Journal Article
Liu, Y; Allingham, RR
Published in: Exp Eye Res
July 2017

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.

Duke Scholars

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

July 2017

Volume

160

Start / End Page

62 / 84

Location

England

Related Subject Headings

  • Retinal Ganglion Cells
  • Phenotype
  • Ophthalmology & Optometry
  • Humans
  • Glaucoma, Open-Angle
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Animals
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, Y., & Allingham, R. R. (2017). Major review: Molecular genetics of primary open-angle glaucoma. Exp Eye Res, 160, 62–84. https://doi.org/10.1016/j.exer.2017.05.002
Liu, Yutao, and R Rand Allingham. “Major review: Molecular genetics of primary open-angle glaucoma.Exp Eye Res 160 (July 2017): 62–84. https://doi.org/10.1016/j.exer.2017.05.002.
Liu Y, Allingham RR. Major review: Molecular genetics of primary open-angle glaucoma. Exp Eye Res. 2017 Jul;160:62–84.
Liu, Yutao, and R. Rand Allingham. “Major review: Molecular genetics of primary open-angle glaucoma.Exp Eye Res, vol. 160, July 2017, pp. 62–84. Pubmed, doi:10.1016/j.exer.2017.05.002.
Liu Y, Allingham RR. Major review: Molecular genetics of primary open-angle glaucoma. Exp Eye Res. 2017 Jul;160:62–84.
Journal cover image

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

July 2017

Volume

160

Start / End Page

62 / 84

Location

England

Related Subject Headings

  • Retinal Ganglion Cells
  • Phenotype
  • Ophthalmology & Optometry
  • Humans
  • Glaucoma, Open-Angle
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Animals
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry