Major review: Molecular genetics of primary open-angle glaucoma.
Published
Journal Article (Review)
Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.
Full Text
Duke Authors
Cited Authors
- Liu, Y; Allingham, RR
Published Date
- July 2017
Published In
Volume / Issue
- 160 /
Start / End Page
- 62 - 84
PubMed ID
- 28499933
Pubmed Central ID
- 28499933
Electronic International Standard Serial Number (EISSN)
- 1096-0007
Digital Object Identifier (DOI)
- 10.1016/j.exer.2017.05.002
Language
- eng
Conference Location
- England