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Genetic Variants in WNT2B and BTRC Predict Melanoma Survival.

Publication ,  Journal Article
Shi, Q; Liu, H; Han, P; Li, C; Wang, Y; Wu, W; Zhu, D; Amos, CI; Fang, S; Lee, JE; Han, J; Wei, Q
Published in: J Invest Dermatol
August 2017

Cutaneous melanoma (CM) is the most lethal skin cancer. The Wnt pathway has an impact on development, invasion, and metastasis of CM, thus likely affecting CM prognosis. Using data from a published genome-wide association study from The University of Texas MD Anderson Cancer Center, we assessed the associations of 19,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autosomal genes with CM-specific survival and then validated significant SNPs in another genome-wide association study from Harvard University. In the single-locus analysis, 1,855 SNPs were significantly associated with CM-specific survival at P < 0.05, of which 547 SNPs were still considered noteworthy after the correction by the false-positive report probability. In the replication, two SNPs remained significantly associated with CM-specific survival after multiple comparison correction. By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 × 10-5) and 0.61 (0.46-0.80, 3.12×10-4), respectively. Collectively, these variants in the Wnt pathway genes may be biomarkers for outcomes of patients with CM, if validated by larger studies.

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Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

August 2017

Volume

137

Issue

8

Start / End Page

1749 / 1756

Location

United States

Related Subject Headings

  • beta-Transducin Repeat-Containing Proteins
  • Young Adult
  • Wnt Signaling Pathway
  • Wnt Proteins
  • United States
  • Survival Rate
  • Skin Neoplasms
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Middle Aged
 

Citation

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Shi, Q., Liu, H., Han, P., Li, C., Wang, Y., Wu, W., … Wei, Q. (2017). Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. J Invest Dermatol, 137(8), 1749–1756. https://doi.org/10.1016/j.jid.2017.04.023
Shi, Qiong, Hongliang Liu, Peng Han, Chunying Li, Yanru Wang, Wenting Wu, Dakai Zhu, et al. “Genetic Variants in WNT2B and BTRC Predict Melanoma Survival.J Invest Dermatol 137, no. 8 (August 2017): 1749–56. https://doi.org/10.1016/j.jid.2017.04.023.
Shi Q, Liu H, Han P, Li C, Wang Y, Wu W, et al. Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. J Invest Dermatol. 2017 Aug;137(8):1749–56.
Shi, Qiong, et al. “Genetic Variants in WNT2B and BTRC Predict Melanoma Survival.J Invest Dermatol, vol. 137, no. 8, Aug. 2017, pp. 1749–56. Pubmed, doi:10.1016/j.jid.2017.04.023.
Shi Q, Liu H, Han P, Li C, Wang Y, Wu W, Zhu D, Amos CI, Fang S, Lee JE, Han J, Wei Q. Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. J Invest Dermatol. 2017 Aug;137(8):1749–1756.
Journal cover image

Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

August 2017

Volume

137

Issue

8

Start / End Page

1749 / 1756

Location

United States

Related Subject Headings

  • beta-Transducin Repeat-Containing Proteins
  • Young Adult
  • Wnt Signaling Pathway
  • Wnt Proteins
  • United States
  • Survival Rate
  • Skin Neoplasms
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Middle Aged