Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies.

Journal Article

The estrogen receptor plays a critical role in the pathogenesis and clinical behavior of breast cancer. To better understand the molecular basis of estrogen-dependent forms of this disease we studied gene expression profiles from 53 primary breast cancer biopsies. Gene expression data for more than 7000 genes were generated from each tumor sample with oligo microarrays. A standard correlation-clustering algorithm identified 18 genes that co-clustered with estrogen receptor alpha. Eleven of these genes had previously been associated with estrogen regulation or breast tumorigenesis including trefoil factor 1 and estrogen regulated LIV-1. Additional study of these 18 genes may further delineate the role of estrogen receptor in breast cancer, generate new predictive biomarkers for response to endocrine therapies and identify novel therapeutic targets.

Full Text

Duke Authors

Cited Authors

  • Dressman, MA; Walz, TM; Lavedan, C; Barnes, L; Buchholtz, S; Kwon, I; Ellis, MJ; Polymeropoulos, MH

Published Date

  • January 2001

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 135 - 141

PubMed ID

  • 11911440

Electronic International Standard Serial Number (EISSN)

  • 1473-1150

International Standard Serial Number (ISSN)

  • 1470-269X

Digital Object Identifier (DOI)

  • 10.1038/sj.tpj.6500022

Language

  • eng