A systematic review of quality-of-life domains and items relevant to patients with spondyloarthritis.

Journal Article (Journal Article;Review;Systematic Review)

OBJECTIVES: To summarize, from the literature, quality-of-life (QoL) domains and items relevant to patients with spondyloarthritis (SpA), and to determine if commonly used SpA patient-reported outcome (PRO) instruments include the identified domains. METHODS: We used PRISMA statement for systematic review and searched Medline® , Embase®, and PsycInfo® using relevant keywords. In addition, hand searches of references of the included articles were conducted. All articles were reviewed for inclusion by 2 independent reviewers. QoL domains and items relevant to patients with axial or peripheral SpA were extracted and presented using the adapted World Health Organization Quality-of-Life (WHOQOL) domain framework. SpA PROs were assessed to determine if they included the domains identified. RESULTS: We retrieved 14,343 articles, of which 34 articles fulfilled inclusion criteria for review. Twenty-five articles were conducted in the European population. Domains such as negative feelings and activities of daily living were found to be present in 28 and 27 articles, respectively. SpA impacted QoL in all domains of the adapted WHOQOL framework. Domains that differed between types of SpA were financial resources, general levels of independence and medication side effects. Embarrassment, self-image, and premature ageing were items that differed by geographical setting. PROs to capture domains for peripheral SpA were similar for axial SpA. CONCLUSIONS: We found that a wide range of domains and items of QoL were relevant to patients with SpA with minimal differences between patients with axial and peripheral SpA. Clinicians may consider using peripheral SpA PROs to measure QoL of patients with axial SpA.

Full Text

Duke Authors

Cited Authors

  • Kwan, YH; Fong, W; Tan, VIC; Lui, NL; Malhotra, R; Østbye, T; Thumboo, J

Published Date

  • October 2017

Published In

Volume / Issue

  • 47 / 2

Start / End Page

  • 175 - 182

PubMed ID

  • 28487138

Electronic International Standard Serial Number (EISSN)

  • 1532-866X

Digital Object Identifier (DOI)

  • 10.1016/j.semarthrit.2017.04.002


  • eng

Conference Location

  • United States