Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development.

Journal Article (Journal Article;Review)

The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that allow nuclear transcription factors and chromatin regulatory proteins to encode aspects of specificity in experience-dependent synapse development. Here we review the evidence for the transcriptional mechanisms that sculpt activity-dependent aspects of synaptic connectivity during postnatal development and discuss how disruption of these processes is associated with aberrant brain development in autism and intellectual disability.

Full Text

Duke Authors

Cited Authors

  • Chen, L-F; Zhou, AS; West, AE

Published Date

  • August 1, 2017

Published In

Volume / Issue

  • 118 / 2

Start / End Page

  • 755 - 770

PubMed ID

  • 28490640

Pubmed Central ID

  • PMC5539463

Electronic International Standard Serial Number (EISSN)

  • 1522-1598

Digital Object Identifier (DOI)

  • 10.1152/jn.00067.2017


  • eng

Conference Location

  • United States