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Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development.

Publication ,  Journal Article
Chen, L-F; Zhou, AS; West, AE
Published in: J Neurophysiol
August 1, 2017

The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that allow nuclear transcription factors and chromatin regulatory proteins to encode aspects of specificity in experience-dependent synapse development. Here we review the evidence for the transcriptional mechanisms that sculpt activity-dependent aspects of synaptic connectivity during postnatal development and discuss how disruption of these processes is associated with aberrant brain development in autism and intellectual disability.

Duke Scholars

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Published In

J Neurophysiol

DOI

EISSN

1522-1598

Publication Date

August 1, 2017

Volume

118

Issue

2

Start / End Page

755 / 770

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Synapses
  • Neurology & Neurosurgery
  • Neural Pathways
  • Humans
  • Connectome
  • Chromatin
  • Brain
  • Animals
 

Citation

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ICMJE
MLA
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Chen, L.-F., Zhou, A. S., & West, A. E. (2017). Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development. J Neurophysiol, 118(2), 755–770. https://doi.org/10.1152/jn.00067.2017
Chen, Liang-Fu, Allen S. Zhou, and Anne E. West. “Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development.J Neurophysiol 118, no. 2 (August 1, 2017): 755–70. https://doi.org/10.1152/jn.00067.2017.
Chen, Liang-Fu, et al. “Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development.J Neurophysiol, vol. 118, no. 2, Aug. 2017, pp. 755–70. Pubmed, doi:10.1152/jn.00067.2017.

Published In

J Neurophysiol

DOI

EISSN

1522-1598

Publication Date

August 1, 2017

Volume

118

Issue

2

Start / End Page

755 / 770

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Synapses
  • Neurology & Neurosurgery
  • Neural Pathways
  • Humans
  • Connectome
  • Chromatin
  • Brain
  • Animals