Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex.

Published

Journal Article

Olfactory perception and behaviors critically depend on the ability to identify an odor across a wide range of concentrations. Here, we use calcium imaging to determine how odor identity is encoded in olfactory cortex. We find that, despite considerable trial-to-trial variability, odor identity can accurately be decoded from ensembles of co-active neurons that are distributed across piriform cortex without any apparent spatial organization. However, piriform response patterns change substantially over a 100-fold change in odor concentration, apparently degrading the population representation of odor identity. We show that this problem can be resolved by decoding odor identity from a subpopulation of concentration-invariant piriform neurons. These concentration-invariant neurons are overrepresented in piriform cortex but not in olfactory bulb mitral and tufted cells. We therefore propose that distinct perceptual features of odors are encoded in independent subnetworks of neurons in the olfactory cortex.

Full Text

Duke Authors

Cited Authors

  • Roland, B; Deneux, T; Franks, KM; Bathellier, B; Fleischmann, A

Published Date

  • May 10, 2017

Published In

Volume / Issue

  • 6 /

PubMed ID

  • 28489003

Pubmed Central ID

  • 28489003

Electronic International Standard Serial Number (EISSN)

  • 2050-084X

International Standard Serial Number (ISSN)

  • 2050-084X

Digital Object Identifier (DOI)

  • 10.7554/eLife.26337

Language

  • eng