The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors.

Journal Article (Journal Article;Review)

The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion, βarrs adopt multiple conformations and are regulated at multiple levels to differentially activate downstream pathways. Recent structural studies have demonstrated that βarrs have a conserved structure and activation mechanism, with plasticity of their structural fold, allowing them to adopt a wide array of conformations. Novel roles for βarrs continue to be identified, demonstrating the importance of these dynamic regulators of cellular signaling.

Full Text

Duke Authors

Cited Authors

  • Smith, JS; Rajagopal, S

Published Date

  • April 22, 2016

Published In

Volume / Issue

  • 291 / 17

Start / End Page

  • 8969 - 8977

PubMed ID

  • 26984408

Pubmed Central ID

  • PMC4861465

Electronic International Standard Serial Number (EISSN)

  • 1083-351X

Digital Object Identifier (DOI)

  • 10.1074/jbc.R115.713313


  • eng

Conference Location

  • United States