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SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila.

Publication ,  Journal Article
Rizzo, NP; Bejsovec, A
Published in: Development (Cambridge, England)
June 2017

During development, extracellular signals are integrated by cells to induce the transcriptional circuitry that controls morphogenesis. In the fly epidermis, Wingless (Wg)/Wnt signaling directs cells to produce either a distinctly shaped denticle or no denticle, resulting in a segmental pattern of denticle belts separated by smooth, or 'naked', cuticle. Naked cuticle results from Wg repression of shavenbaby (svb), which encodes a transcription factor required for denticle construction. We have discovered that although the svb promoter responds differentially to altered Wg levels, Svb alone cannot produce the morphological diversity of denticles found in wild-type belts. Instead, a second Wg-responsive transcription factor, SoxNeuro (SoxN), cooperates with Svb to shape the denticles. Co-expressing ectopic SoxN with svb rescued diverse denticle morphologies. Conversely, removing SoxN activity eliminated the residual denticles found in svb mutant embryos. Furthermore, several known Svb target genes are also activated by SoxN, and we have discovered two novel target genes of SoxN that are expressed in denticle-producing cells and that are regulated independently of Svb. We conclude that proper denticle morphogenesis requires transcriptional regulation by both SoxN and Svb.

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Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

June 2017

Volume

144

Issue

12

Start / End Page

2248 / 2258

Related Subject Headings

  • Wnt1 Protein
  • Transcription Factors
  • Signal Transduction
  • SOX Transcription Factors
  • Promoter Regions, Genetic
  • Mutation
  • Morphogenesis
  • Models, Biological
  • Genes, Insect
  • Gene Expression Regulation, Developmental
 

Citation

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Rizzo, N. P., & Bejsovec, A. (2017). SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila. Development (Cambridge, England), 144(12), 2248–2258. https://doi.org/10.1242/dev.150169
Rizzo, Nicholas P., and Amy Bejsovec. “SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila.Development (Cambridge, England) 144, no. 12 (June 2017): 2248–58. https://doi.org/10.1242/dev.150169.
Rizzo NP, Bejsovec A. SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila. Development (Cambridge, England). 2017 Jun;144(12):2248–58.
Rizzo, Nicholas P., and Amy Bejsovec. “SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila.Development (Cambridge, England), vol. 144, no. 12, June 2017, pp. 2248–58. Epmc, doi:10.1242/dev.150169.
Rizzo NP, Bejsovec A. SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila. Development (Cambridge, England). 2017 Jun;144(12):2248–2258.
Journal cover image

Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

June 2017

Volume

144

Issue

12

Start / End Page

2248 / 2258

Related Subject Headings

  • Wnt1 Protein
  • Transcription Factors
  • Signal Transduction
  • SOX Transcription Factors
  • Promoter Regions, Genetic
  • Mutation
  • Morphogenesis
  • Models, Biological
  • Genes, Insect
  • Gene Expression Regulation, Developmental