Review of Recent Methodological Developments in Group-Randomized Trials: Part 2-Analysis.

Journal Article (Journal Article;Review)

In 2004, Murray et al. reviewed methodological developments in the design and analysis of group-randomized trials (GRTs). We have updated that review with developments in analysis of the past 13 years, with a companion article to focus on developments in design. We discuss developments in the topics of the earlier review (e.g., methods for parallel-arm GRTs, individually randomized group-treatment trials, and missing data) and in new topics, including methods to account for multiple-level clustering and alternative estimation methods (e.g., augmented generalized estimating equations, targeted maximum likelihood, and quadratic inference functions). In addition, we describe developments in analysis of alternative group designs (including stepped-wedge GRTs, network-randomized trials, and pseudocluster randomized trials), which require clustering to be accounted for in their design and analysis.

Full Text

Duke Authors

Cited Authors

  • Turner, EL; Prague, M; Gallis, JA; Li, F; Murray, DM

Published Date

  • July 2017

Published In

Volume / Issue

  • 107 / 7

Start / End Page

  • 1078 - 1086

PubMed ID

  • 28520480

Pubmed Central ID

  • PMC5463203

Electronic International Standard Serial Number (EISSN)

  • 1541-0048

Digital Object Identifier (DOI)

  • 10.2105/AJPH.2017.303707


  • eng

Conference Location

  • United States