A cross-sectional structured survey of patients receiving botulinum toxin type A treatment for blepharospasm.

Journal Article (Journal Article)

To characterize satisfaction with current standard-of-care botulinum neurotoxin type A (BoNT/A) treatment for blepharospasm, we performed a cross-sectional, structured survey in subjects with blepharospasm who had received ≥2 BoNT/A cycles. Subjects were interviewed immediately before re-injection to evaluate treatment satisfaction, time course of treatment effects, preferred injection intervals, Jankovic Rating Scale (JRS), and Blepharospasm Disability Index (BSDI). Subjects' (n=114) last treatment was onabotulinumtoxinA (n=78), incobotulinumtoxinA (n=35), or abobotulinumtoxinA (n=1). The most frequent injection interval was 12weeks (46.5% subjects); 30.7% had an interval >12weeks. The main rationale for interval choice was "to maintain treatment efficacy" (44.7%). However, 36.6% reported that treatment effects usually declined within 8weeks; 69.6% within 10weeks. JRS and BSDI scores indicated re-emergence of symptoms before re-injection, with 70.2% and 73.7% of subjects reporting difficulties to drive and read, respectively. Overall, treatment satisfaction was high, but declined at the end of the cycle. Many subjects (52.3%) would prefer an injection interval of <12weeks; 30.6% of <10weeks. In conclusion, the survey results indicate that blepharospasm symptoms, such as difficulties to drive and read, re-emerge at the end of a BoNT treatment cycle and that flexible, individualized treatment intervals may improve treatment satisfaction and outcomes.

Full Text

Duke Authors

Cited Authors

  • Fezza, J; Burns, J; Woodward, J; Truong, D; Hedges, T; Verma, A

Published Date

  • August 15, 2016

Published In

Volume / Issue

  • 367 /

Start / End Page

  • 56 - 62

PubMed ID

  • 27423565

Electronic International Standard Serial Number (EISSN)

  • 1878-5883

Digital Object Identifier (DOI)

  • 10.1016/j.jns.2016.05.033


  • eng

Conference Location

  • Netherlands