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SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer.

Publication ,  Journal Article
Onxley, J; Yoo, D; Muradyan, N; MacFall, J; Brizel, D; Craciunescu, O
Published in: Med Phys
June 2012

PURPOSE: To generate a composite population-averaged(PA)-AIF for quantitative analysis of DCE-MRI data in head and neck (H&N) patients that is based on the right (RT) and left (LT) carotids, two pre-treatment scans, and one post-treatment scan. METHODS: Twenty patients were imaged while undergoing concurrent chemoradiation (CRT) for H&N malignancies. The imaging protocol (1) included two baseline scans one week apart (Base1, Base2), and one scan 1 week post-CRT (Post). For each patient and time point, regions of interest (ROIs) in both the RT and LT carotids were drawn on coronal images. The plasma concentration curves of all ROIs were averaged and fit to a bi-exponential decay function to obtain the final PA- AIF (AvgAll). The ROIs were also divided by time point to obtain AvgBasel, AvgBase2, and AvgPost AIFs. The vascular transfer constant for both primary and nodes, Ktrans , was calculated (iCAD, Inc.) using the 4 AIFs, as well as the generic Weinmann's AIF. The median Ktrans values resulting from the AvgAll AIF were compared using Bland-Altman plots with the ones obtained from each individual time point. The Wilcoxon signed-rank test was used to compare the proposed AvgAll AIF and the generic AIF. RESULTS: The plasma parameters for the AvgAll AIF were a1,2=27.1135/17.6486 kg/liter, m 1,2=11.7525/0.2054 min-1 . The differences in Ktrans values using these coefficients vs. Weinmann's were statistically significant (p<0.0001). The median Ktrans values from the AvgBasel,AvgBase2, and AvgPost AIFs were, in most cases, not significantly different from the AvgAll values, indicating that the latter is appropriate foruse at all time points. CONCLUSIONS: A population-averaged AIF for H&N was generated that accounts for differences in RT vs. LT carotids, day-today AIF fluctuations, and treatment-induced AIF changes. It is not necessary to measure a post-treatment AIF to evaluate treatment-induced Ktrans changes.l. Craciunescu et al., MedPhys, 37, 6, 2683, 2010.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2012

Volume

39

Issue

6Part3

Start / End Page

3615 / 3616

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Onxley, J., Yoo, D., Muradyan, N., MacFall, J., Brizel, D., & Craciunescu, O. (2012). SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer. Med Phys, 39(6Part3), 3615–3616. https://doi.org/10.1118/1.4734678
Onxley, J., D. Yoo, N. Muradyan, J. MacFall, D. Brizel, and O. Craciunescu. “SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer.Med Phys 39, no. 6Part3 (June 2012): 3615–16. https://doi.org/10.1118/1.4734678.
Onxley J, Yoo D, Muradyan N, MacFall J, Brizel D, Craciunescu O. SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer. Med Phys. 2012 Jun;39(6Part3):3615–6.
Onxley, J., et al. “SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer.Med Phys, vol. 39, no. 6Part3, June 2012, pp. 3615–16. Pubmed, doi:10.1118/1.4734678.
Onxley J, Yoo D, Muradyan N, MacFall J, Brizel D, Craciunescu O. SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer. Med Phys. 2012 Jun;39(6Part3):3615–3616.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2012

Volume

39

Issue

6Part3

Start / End Page

3615 / 3616

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences