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"We Need to Deploy Them Very Thoughtfully and Carefully": Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States-A Qualitative Inquiry.

Publication ,  Journal Article
Dubé, K; Evans, D; Dee, L; Sylla, L; Taylor, J; Skinner, A; Weiner, BJ; Greene, SB; Rennie, S; Tucker, JD
Published in: AIDS Res Hum Retroviruses
January 2018

Strategies to control HIV in the absence of antiretroviral therapy are needed to cure HIV. However, such strategies will require analytical treatment interruptions (ATIs) to determine their efficacy. We investigated how U.S. stakeholders involved in HIV cure research perceive ATIs. We conducted 36 in-depth interviews with three groups of stakeholders: 12 people living with HIV, 11 clinician-researchers, and 13 policy-makers/bioethicists. Qualitative data revealed several themes. First, there was little consensus on when ATIs would be ethically warranted. Second, the most frequent perceived hypothetical motivators for participating in research on ATIs were advancing science and contributing to society. Third, risks related to viral rebound were the most prevalent concerns related to ATIs. Stakeholders suggested ways to minimize the risks of ATIs in HIV cure research. Increased cooperation between scientists and local communities may be useful for minimizing risk. Further ethics research is necessary.

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Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

January 2018

Volume

34

Issue

1

Start / End Page

67 / 79

Location

United States

Related Subject Headings

  • Virology
  • United States
  • Time-to-Treatment
  • Qualitative Research
  • Male
  • Intersectoral Collaboration
  • Humans
  • HIV Infections
  • Female
  • Biomedical Research
 

Citation

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Dubé, K., Evans, D., Dee, L., Sylla, L., Taylor, J., Skinner, A., … Tucker, J. D. (2018). "We Need to Deploy Them Very Thoughtfully and Carefully": Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States-A Qualitative Inquiry. AIDS Res Hum Retroviruses, 34(1), 67–79. https://doi.org/10.1089/AID.2017.0067
Dubé, Karine, David Evans, Lynda Dee, Laurie Sylla, Jeff Taylor, Asheley Skinner, Bryan J. Weiner, Sandra B. Greene, Stuart Rennie, and Joseph D. Tucker. “"We Need to Deploy Them Very Thoughtfully and Carefully": Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States-A Qualitative Inquiry.AIDS Res Hum Retroviruses 34, no. 1 (January 2018): 67–79. https://doi.org/10.1089/AID.2017.0067.
Dubé, Karine, et al. “"We Need to Deploy Them Very Thoughtfully and Carefully": Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States-A Qualitative Inquiry.AIDS Res Hum Retroviruses, vol. 34, no. 1, Jan. 2018, pp. 67–79. Pubmed, doi:10.1089/AID.2017.0067.
Dubé K, Evans D, Dee L, Sylla L, Taylor J, Skinner A, Weiner BJ, Greene SB, Rennie S, Tucker JD. "We Need to Deploy Them Very Thoughtfully and Carefully": Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States-A Qualitative Inquiry. AIDS Res Hum Retroviruses. 2018 Jan;34(1):67–79.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

January 2018

Volume

34

Issue

1

Start / End Page

67 / 79

Location

United States

Related Subject Headings

  • Virology
  • United States
  • Time-to-Treatment
  • Qualitative Research
  • Male
  • Intersectoral Collaboration
  • Humans
  • HIV Infections
  • Female
  • Biomedical Research