Knowns and unknowns of membrane lipid synthesis in streptomycetes.

Journal Article (Journal Article;Review)

Bacteria belonging to the genus Streptomyces are among the most prolific producers of antibiotics. Research on cellular membrane biosynthesis and turnover is lagging behind in Streptomyces compared to related organisms like Mycobacterium tuberculosis. While natural products discovery in Streptomyces is evidently a priority in order to discover new antibiotics to combat the increase in antibiotic resistant pathogens, a better understanding of this cellular compartment should provide insights into the interplay between core and secondary metabolism. However, some of the pathways for membrane lipid biosynthesis are still incomplete. In addition, while it has become clear that remodelling of the membrane is necessary for coping with environmental stress and for morphological differentiation, the detailed mechanisms of these adaptations remain elusive. Here, we aim to provide a summary of what is known about the polar lipid composition in Streptomyces, the biosynthetic pathways of polar lipids, and to highlight current gaps in understanding function, dynamics and biosynthesis of these essential molecules.

Full Text

Duke Authors

Cited Authors

  • Sandoval-Calderón, M; Guan, Z; Sohlenkamp, C

Published Date

  • October 2017

Published In

Volume / Issue

  • 141 /

Start / End Page

  • 21 - 29

PubMed ID

  • 28522365

Pubmed Central ID

  • PMC5610088

Electronic International Standard Serial Number (EISSN)

  • 1638-6183

Digital Object Identifier (DOI)

  • 10.1016/j.biochi.2017.05.008

Language

  • eng

Conference Location

  • France