Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.

Journal Article (Journal Article)

This protocol describes a series of approaches to measure feedforward inhibition in acute brain slices from the cerebellar cortex. Using whole-cell voltage and current clamp recordings from Purkinje cells in conjunction with electrical stimulation of the parallel fibers, these methods demonstrate how to measure the relationship between excitation and inhibition in a feedforward circuit. This protocol also describes how to measure the impact of feedforward inhibition on Purkinje cell excitability, with an emphasis on spike timing.

Full Text

Duke Authors

Cited Authors

  • Hull, C

Published Date

  • May 1, 2017

Published In

Volume / Issue

  • 2017 / 5

PubMed ID

  • 28461661

Pubmed Central ID

  • PMC6371772

Electronic International Standard Serial Number (EISSN)

  • 1559-6095

Digital Object Identifier (DOI)

  • 10.1101/pdb.prot095828


  • eng

Conference Location

  • United States