Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.
Publication
, Journal Article
Hull, C
Published in: Cold Spring Harb Protoc
May 1, 2017
This protocol describes a series of approaches to measure feedforward inhibition in acute brain slices from the cerebellar cortex. Using whole-cell voltage and current clamp recordings from Purkinje cells in conjunction with electrical stimulation of the parallel fibers, these methods demonstrate how to measure the relationship between excitation and inhibition in a feedforward circuit. This protocol also describes how to measure the impact of feedforward inhibition on Purkinje cell excitability, with an emphasis on spike timing.
Duke Scholars
Published In
Cold Spring Harb Protoc
DOI
EISSN
1559-6095
Publication Date
May 1, 2017
Volume
2017
Issue
5
Location
United States
Related Subject Headings
- Synapses
- Purkinje Cells
- Patch-Clamp Techniques
- Membrane Potentials
- Evoked Potentials
- Electrophysiological Phenomena
- Electric Stimulation
- Cerebellar Cortex
- Animals
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Hull, C. (2017). Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. Cold Spring Harb Protoc, 2017(5). https://doi.org/10.1101/pdb.prot095828
Hull, Court. “Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.” Cold Spring Harb Protoc 2017, no. 5 (May 1, 2017). https://doi.org/10.1101/pdb.prot095828.
Hull C. Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. Cold Spring Harb Protoc. 2017 May 1;2017(5).
Hull, Court. “Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.” Cold Spring Harb Protoc, vol. 2017, no. 5, May 2017. Pubmed, doi:10.1101/pdb.prot095828.
Hull C. Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. Cold Spring Harb Protoc. 2017 May 1;2017(5).
Published In
Cold Spring Harb Protoc
DOI
EISSN
1559-6095
Publication Date
May 1, 2017
Volume
2017
Issue
5
Location
United States
Related Subject Headings
- Synapses
- Purkinje Cells
- Patch-Clamp Techniques
- Membrane Potentials
- Evoked Potentials
- Electrophysiological Phenomena
- Electric Stimulation
- Cerebellar Cortex
- Animals
- 3101 Biochemistry and cell biology