WE-E-BRB-04: Quantitative Dose Tracking Enabled Through a Novel Deformable 3D Dosimeter.

Published

Journal Article

PURPOSE: To evaluate and investigate the feasibility of a new method for validating dose tracking algorithms in deforming tissues using a novel deformable 3D dosimeter. METHODS: A novel deformable 3D Presage dosimeter is reported consisting of a stretchy polyurethane matrix doped with radiochromic leuco-dye. Two deformable cylindrical dosimeters (6 cm diameter, 5 cm long) were manufactured and irradiated with a checkerboard arrangement of 5 mm square pencil beams created by MLC fields. One dosimeter was irradiated under lateral compression by 33% (6 cm down to 4 cm diameter) to simulate a deformed organ. A second control dosimeter was irradiated with the same checkerboard pattern but without deformation applied. High-resolution 3D dose distributions (isotropic 1 mm resolution) were obtained by optical-CT imaging. Physical dose deformation was quantified by comparing checkerboard pencil beam shapes and positions in the deformed and control dosimeters. RESULTS: Deformation of dose in the deformed dosimeter was clearly visible in all 3 dimensions. The deformed checkerboard dose pattern showed expansion of 16% - 46% along the axis of compression, with higher expansion observed in the central regions of the dosimeter. Perpendicular to the compression axis, the dose pattern contracted by 7% - 13%. Peak dose changes of -6% and +30% were observed parallel and perpendicular to the compression axis respectively. Dose response was linear from 0-8 Gy. CONCLUSIONS: Dose tracking was successfully quantified in a novel deforming 3D dosimeter. This capability has potential as a powerful new method for validating deformable dose tracking and registration algorithms. NCI R01CA100835.

Full Text

Duke Authors

Cited Authors

  • Juang, T; Newton, J; Das, S; Adamovics, J; Oldham, M

Published Date

  • June 2012

Published In

Volume / Issue

  • 39 / 6Part27

Start / End Page

  • 3956 -

PubMed ID

  • 28519995

Pubmed Central ID

  • 28519995

Electronic International Standard Serial Number (EISSN)

  • 2473-4209

Digital Object Identifier (DOI)

  • 10.1118/1.4736146

Language

  • eng

Conference Location

  • United States