Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques.

Published

Journal Article

Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.

Full Text

Duke Authors

Cited Authors

  • Nguyen, SM; Antony, KM; Dudley, DM; Kohn, S; Simmons, HA; Wolfe, B; Salamat, MS; Teixeira, LBC; Wiepz, GJ; Thoong, TH; Aliota, MT; Weiler, AM; Barry, GL; Weisgrau, KL; Vosler, LJ; Mohns, MS; Breitbach, ME; Stewart, LM; Rasheed, MN; Newman, CM; Graham, ME; Wieben, OE; Turski, PA; Johnson, KM; Post, J; Hayes, JM; Schultz-Darken, N; Schotzko, ML; Eudailey, JA; Permar, SR; Rakasz, EG; Mohr, EL; Capuano, S; Tarantal, AF; Osorio, JE; O'Connor, SL; Friedrich, TC; O'Connor, DH; Golos, TG

Published Date

  • May 25, 2017

Published In

Volume / Issue

  • 13 / 5

Start / End Page

  • e1006378 -

PubMed ID

  • 28542585

Pubmed Central ID

  • 28542585

Electronic International Standard Serial Number (EISSN)

  • 1553-7374

International Standard Serial Number (ISSN)

  • 1553-7366

Digital Object Identifier (DOI)

  • 10.1371/journal.ppat.1006378

Language

  • eng