Change the management of patients with heart failure: Rationale and design of the CHAMP-HF registry.


Journal Article

Heart failure (HF) with reduced ejection fraction (HFrEF) is a common and costly condition that diminishes patients' health status and confers a poor prognosis. Despite the availability of multiple guideline-recommended pharmacologic and cardiac device therapies for patients with chronic HFrEF, outcomes remain suboptimal. Currently, there is limited insight into the rationale underlying clinical decisions by health care providers and patient factors that guide the use and intensity of outpatient HF treatments. A better understanding of current practice patterns has the potential to improve patients' outcomes. The CHAnge the Management of Patients with Heart Failure (CHAMP-HF) registry will evaluate the care and outcomes of patients with chronic HFrEF by assessing real-world treatment patterns, as well as the reasons for and barriers to medication treatment changes. CHAMP-HF will enroll approximately 5,000 patients with chronic HFrEF (left ventricular ejection fraction ≤40%) at approximately 150 US sites, and patients will be followed for a maximum duration of 24 months. Participating sites will collect data from both providers (HF history, examination findings, results of diagnostic studies, pharmacotherapy treatment patterns, decision-making factors, and clinical outcomes) and patients (medication adherence and patient-reported outcomes). The CHAMP-HF registry will provide a unique opportunity to study practice patterns and the adoption of new HF therapies across a diverse mix of health care providers and outpatient practices in the United States that care for HFrEF patients.

Full Text

Duke Authors

Cited Authors

  • DeVore, AD; Thomas, L; Albert, NM; Butler, J; Hernandez, AF; Patterson, JH; Spertus, JA; Williams, FB; Turner, SJ; Chan, WW; Duffy, CI; McCague, K; Mi, X; Fonarow, GC

Published Date

  • July 2017

Published In

Volume / Issue

  • 189 /

Start / End Page

  • 177 - 183

PubMed ID

  • 28625374

Pubmed Central ID

  • 28625374

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2017.04.010


  • eng

Conference Location

  • United States