An Epstein-Barr virus-positive classical Hodgkin lymphoma with exclusive sinusoidal growth pattern: An unusual morphologic variant.

Journal Article (Journal Article)

Classical Hodgkin lymphoma (cHL) typically involves lymph node parenchyma, and a case with Hodgkin cells confined within nodal sinusoids is extremely rare. Herein we report a case of cHL with a sinusoidal growth pattern. This 15-year old patient presented with B symptoms and was found to have bilateral cervical lymphadenopathy and an anterior mediastinal mass. Biopsy of a cervical lymph node demonstrated cohesive clusters of Reed-Sternberg (RS)-like cells suggestive of sinusoidal growth with an extrasinusoidal mixed inflammatory cell infiltrate characteristic of the microenvironment seen in cHL. The RS cells/variants were positive for CD30 and CD15, and showed down-regulation of B-cell program and CD45, an immunophenotypic profile consistent with cHL. The sinusoidal growth pattern was also highlighted by EBV staining. To the best of our knowledge, this is the first case of EBV-positive cHL that displays a sinusoidal growth pattern. The patient was treated with children's high risk cHL chemotherapy protocol and responded well.

Full Text

Duke Authors

Cited Authors

  • Su, P; Jug, R; Liu, X; Wang, E

Published Date

  • June 2017

Published In

Volume / Issue

  • 213 / 6

Start / End Page

  • 710 - 712

PubMed ID

  • 28552534

Electronic International Standard Serial Number (EISSN)

  • 1618-0631

Digital Object Identifier (DOI)

  • 10.1016/j.prp.2017.02.018


  • eng

Conference Location

  • Germany