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Systemic Therapy for Non-Clear Cell Renal Cell Carcinoma.

Publication ,  Journal Article
Zhang, T; Gong, J; Maia, MC; Pal, SK
Published in: Am Soc Clin Oncol Educ Book
2017

Treatment options for metastatic clear cell renal cell carcinoma (ccRCC) have evolved markedly over the past decade, with multiple targeted therapies approved for the disease. In contrast, little improvement has been made in the management of metastatic non-clear cell RCC (nccRCC). Non-clear cell disease is an umbrella term that encompasses multiple biologically distinct entities, including but not limited to papillary, chromophobe, and sarcomatoid RCC. To date, prospective studies have largely explored treatments for ccRCC (e.g., VEGF- and mTOR-directed therapies) in trials that aggregate non-clear cell histologies. However, the studies do not acknowledge the varying biology of each non-clear cell subtype. Emerging studies in nccRCC should examine individual histologies and apply biologically relevant therapies. An example of this is SWOG 1500, a randomized phase II study that will compare a VEGF-inhibitor to one of three MET-directed therapies in patients with metastatic papillary RCC. Until the biologic diversity of nccRCC is appreciated, outcomes are likely to remain dismal.

Duke Scholars

Published In

Am Soc Clin Oncol Educ Book

DOI

EISSN

1548-8756

Publication Date

2017

Volume

37

Start / End Page

337 / 342

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • TOR Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-met
  • Molecular Targeted Therapy
  • Humans
  • Carcinoma, Renal Cell
  • Antineoplastic Agents
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Zhang, T., Gong, J., Maia, M. C., & Pal, S. K. (2017). Systemic Therapy for Non-Clear Cell Renal Cell Carcinoma. Am Soc Clin Oncol Educ Book, 37, 337–342. https://doi.org/10.1200/EDBK_175572
Zhang, Tian, Jun Gong, Manuel Caitano Maia, and Sumanta K. Pal. “Systemic Therapy for Non-Clear Cell Renal Cell Carcinoma.Am Soc Clin Oncol Educ Book 37 (2017): 337–42. https://doi.org/10.1200/EDBK_175572.
Zhang T, Gong J, Maia MC, Pal SK. Systemic Therapy for Non-Clear Cell Renal Cell Carcinoma. Am Soc Clin Oncol Educ Book. 2017;37:337–42.
Zhang, Tian, et al. “Systemic Therapy for Non-Clear Cell Renal Cell Carcinoma.Am Soc Clin Oncol Educ Book, vol. 37, 2017, pp. 337–42. Pubmed, doi:10.1200/EDBK_175572.
Zhang T, Gong J, Maia MC, Pal SK. Systemic Therapy for Non-Clear Cell Renal Cell Carcinoma. Am Soc Clin Oncol Educ Book. 2017;37:337–342.

Published In

Am Soc Clin Oncol Educ Book

DOI

EISSN

1548-8756

Publication Date

2017

Volume

37

Start / End Page

337 / 342

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • TOR Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-met
  • Molecular Targeted Therapy
  • Humans
  • Carcinoma, Renal Cell
  • Antineoplastic Agents
  • 3211 Oncology and carcinogenesis