The Basal Ganglia in Action.

Published

Journal Article (Review)

The basal ganglia (BG) are the major subcortical nuclei in the brain. Disorders implicating the BG are characterized by diverse symptoms, but it remains unclear what these symptoms have in common or how they can be explained by changes in the BG circuits. This review summarizes recent findings that not only question traditional assumptions about the role of the BG in movement but also elucidate general computations performed by these circuits. To explain these findings, a new conceptual framework is introduced for understanding the role of the BG in behavior. According to this framework, the cortico-BG networks implement transition control in an extended hierarchy of closed loop negative feedback control systems. The transition control model provides a solution to the posture/movement problem, by postulating that BG outputs send descending signals to alter the reference states of downstream position control systems for orientation and body configuration. It also explains major neurological symptoms associated with BG pathology as a result of changes in system parameters such as multiplicative gain and damping.

Full Text

Duke Authors

Cited Authors

  • Yin, HH

Published Date

  • June 2017

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • 299 - 313

PubMed ID

  • 27306757

Pubmed Central ID

  • 27306757

Electronic International Standard Serial Number (EISSN)

  • 1089-4098

International Standard Serial Number (ISSN)

  • 1073-8584

Digital Object Identifier (DOI)

  • 10.1177/1073858416654115

Language

  • eng